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| MSeminar:
High-throughput Metabolite Identification |
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- Agenda:
High-throughput strategies for the identification of
metabolites utilizing the ultra-fast cycle time and
sensitivity of the Finnigan™ LTQ™ will be presented. The
application of fast LC gradients, automated Data Dependent
operation and Metabolite ID software will be
discussed.
- Speaker: Scott Peterman, Ph.D.; Senior
Application Chemist; Thermo Electron Corporation |
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| Software for
Metabolism Studies |
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| Metabolite ID
& Mass Frontier™ are great tools for your metabolism
identification. Metabolite ID 2.0 helps you generate a list of
possible metabolites, search for any combination of isotopes
and quickly generate reports. Once you have identified a
possible hydroxylated metabolite for instance, Metabolite ID
exports the necessary spectra to Mass Frontier where you can
use several tools to locate the exact site of modification. |
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| Download A
Relevant Application
Note |
| Proteomics
Application: Biomarkers for Hypertrophic
Cardiomyopathy |
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Myocardial
infarction (MI) is a major cause of morbidity and mortality
worldwide, with approximately 500,000-700,000 deaths caused by
ischemic heart disease in the United States each year. The
causes of the disease have been well-established, but the
build-up to a massive heart attack is difficult to predict,
particularly during early stages of disease progression when
prevention is still possible. Proteomics - both large-scale
protein identification and quantitative differential
expression - may be used to identify improved diagnostic
markers and contribute to our understanding of biochemical
pathways triggered during myocardial injury that might one day
serve as targets for drug therapy. |
| Download Full
Application Note |
| Small Molecule
Application: Analysis of Zeaxanthin |
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| (3R,3'R)-zeaxanthin is one of several dietary
carotenoids found in human ocular tissue. Research has shown
that concentrations of zeaxanthin, as well as other
carotenoids, are significantly lower than normal in the macula
of persons diagnosed with neovascular age-related macular
degeneration (AMD). One mechanism by which macular carotenoids
may provide protection against AMD may involve its antioxidant
function. Thus, these carotenoids may be ultimately beneficial
in protecting the eye from light-induced oxidative damage. The
technique used in this report provides a simple and reliable
way of identifying and quantifying zeaxanthin for metabolic
studies. |
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| Download Full
Application Note |
| Posters &
Presentations |
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Learn how
Finnigan mass spectrometers enable new discovery and increase
lab productivity!
The 2004 LC/MS applications CD includes
over 75 posters, presentations and application notes in the
areas of Metabolomics, Forensics, ADME/Tox, Pharmacology,
Proteomics, Bioinformatics, Discovery quantitation and
more... |
| Order the 2004
Thermo LC/MS applications CD
now! |
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| Miscellaneous |
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- The first US HUPO
Symposium will be held March 13-16, 2005 at the
prestigious Crystal Hyatt Hotel, one of Washington DC's finest
facilities. Topics discussed at the symposium will stretch
from the development of new analytical tools and methods that
enhance throughput, structural characterization, and cellular
imaging to the study of functional proteomics, protein:protein
interactions, post-translational modifications, recognition of
stimulus associated changes in the proteomes, and
bioinformatics. Visit Thermo at Booth #9. [More
Information]
- Introduction to the most
sensitive and advanced Triple Quad [Video
Clip]
- Rapid Accurate Protein Identification
[Video
Clip] |
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| Special Ion Trap
Offers |
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Choose from
the following "limited time only" offers:
- Offer
1: Six Ways to Make Your Life Easier in the Lab: Choose
from one of six value-packed hardware or software packages
(Worldwide). With the purchase of a new Finnigan LCQ™ Deca XP MAX, you can qualify
for...
- Offer 2: Increase your instrument
sensitivity and throughput - Trade In and Trade Up your LCQ
Ion Trap (North America Only). Upgrade your Finnigan LCQ ion
trap to the proven performance of the Finnigan LCQ Deca XP MAX
at a substantially lower... |
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| Trap
Talk: Data Dependent™
Neutral Loss & PTMs |
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Post-translational modifications, such as
phosphorylation and glycosylation, are associated with
regulation, location and function of proteins. Phosphoproteins
and glycoproteins are generally found in low quantities within
cells. This low abundance, coupled with the higher acidity of
phosphopeptides and low hydrophobicity of glycoproteins,
complicates their analysis by mass spectrometry in positive
ESI mode. The Data Dependent scan function helps overcome the
characteristic lack of peptide fragmentation... |
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Article |
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