Life Sciences Mass Spectrometry eNewsletter
Critical Mass, Issue 5
November 2004
  Click here to Forward Critical Mass to your Colleague Visit: thermo.com 
On the Web: www.thermo.com/criticalmass
 MSeminar: Mass Spectrometry Web Seminars  
Register now to attend these LIVE Webinars:

- Increased confidence of protein identification using the Finnigan LTQ FT By Helmut Muenster, Ph.D.
- Optimizing the Finnigan TSQ Quantum for high sensitivity - Part II By Rohan Thakur, Ph.D.
Visit www.thermo.com/mseminar to attend!! 

 Center for Proteomics Excellence 2.0  
The Center for Proteomics Excellence 2.0 CD contains a knowledge base of Proteomics Information essential to your everyday Proteomics Research.
The CD contains in an easy to navigate web like format: ----- Application Notes ----- Poster Presentations ----- Product Manuals ----- Links to Literature Abstracts ----- Valuable Tools & Calculators ----- Latest in Proteomics techniques and products ----- Information on essential software ----- List of Proteomics Conferences and more... 
Click here to order your FREE copy today!! 

 Achieve Ultra-low Levels of Quantitative Bioanalysis with H-SRM  
The Finnigan TSQ Quantum series of mass spectrometers are the most advanced and powerful set of triple quadrupole mass spectrometers available in the world today, featuring the patented HyperQuad Quadrupole mass analyzer system, a rugged orthogonal source, and a completely redesigned analyzer geometry for maximum sensitivity, precision, and reliability. One of the key features of the Quantum which sets it apart from any other commercially available triple quadrupole instrument is the ability to carry out H-SRM for quantitative assays.

What is H-SRM ?
H-SRM is an acronym for Highly-Selective Reaction Monitoring, which is a more advanced form of Selective Reaction Monitoring (SRM). SRM is...more
Read Full Article 

 News: Video Clips, Downloads & more...
- Introduction to the most sensitive and advanced Triple Quad [Video Clip].
- Rapid Accurate Protein Identification [Video Clip].
- Biomarker Research Initiatives in Mass Spectrometry (BRIMS) Center Launched [Read Press Release].
- HPLC Analysis of Biomolecules Technical Guide [Order your FREE copy today
 

 Proteomics Applications
- Identification of Glycosylated Peptides from Data Dependent Neutral Loss Scans Using a Linear Ion Trap Mass Spectrometer [Download]
- Complex Peptide Mixture Analysis on the Finnigan LTQ Linear Ion Trap Mass Spectrometer [Download
More Proteomics Applications... 

 What are you doing with your MSn data?
How do you plan to use the MSn data that you generated using your ion trap mass spectrometer? Mass Frontier 4.0 provides a new database structure that allows you to automatically create, store and search your MSn spectra trees. This spectral tree is the structural fingerprint of your molecule, and much more valuable in its entirety than just the full scan MS or MS3 spectrum individually. Additionally, you can continue to enhance this spectral tree by adding any subsequent data from other ion traps or triple quads. 
Learn more about Mass Frontier 4.0 

 Small Molecule Applications
- High Resolution Separation with Accurate Mass Determination of Two Co-Eluting Controlled Drugs of Abuse with Isobaric Mass [Download]
- Simultaneous Detection of 88 Pesticides on the Finnigan TSQ Quantum Discovery Using a Novel LC/MS/MS Method [Download
More Small Molecule Applications... 

 Trap Talk: Data Dependent Neutral Loss  
Phosphorylation is recognized as one of the most important post-translational modifications of proteins, and is associated with many proteins that have a regulatory function in cells. Phosphoproteins are generally found in low quantities within cells. This low abundance, coupled with the higher acidity of phosphopeptides, increases the complexity of their analysis by mass spectrometry in positive ESI mode. In tandem mass spectrometry, phosphopeptide precursor ions typically exhibit a prominent neutral loss of a phosphate group...more 
Download Full Article 

 Profile Part II: George Stafford and 25yrs. of Ion Traps  
George C. Stafford, Jr., Ph.D.

Director of Research
Finnigan Mass Spectrometry
Thermo Electron Corporation
 

 Through the Customer's Eyes
"I really like the new nanospray source because the visualization is so much better. It is much easier to optimize the spray when you can see it, and that improves the data."

-- Kristy J. Brown, Ph.D.
Children's National Medical Center
Center for Genetic Medicine
Washington, DC, USA
 

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