| Please send
Comments & Suggestions to
criticalmass@thermo.com |
| MSeminar:
Mass Spectrometry Web Seminars |
|
 |
Featuring the following LIVE Seminars:
- Finnigan
LTQ FT: The Most Advanced LC-MS and MS/MS System Ever
-
Finnigan TSQ Quantum for Quantitation: An Introduction
-
Environmental Applications for the Finnigan TSQ Quantum:
Chloramphenicol, Perchlorate & CDFA
- Top Down
Proteomics using the Finnigan LTQ FT
- Tuning the Finnigan
TSQ Quantum for high sensitivity and more...
Checkout
the latest schedule!! |
| Preserving
PTMs during Peptide Fragmentation |
|
 |
During the last several years, Electron Capture
Dissociation (ECD) has rapidly evolved as an ideal alternative
activation method for peptide and protein sequencing in
Fourier-transform ion cyclotron resonance-mass spectrometry
(FTICR-MS).
The Finnigan LTQ FT hybrid linear ion trap ICR
mass spectrometer for the first time provides a means to
perform ECD analysis on complex mixtures of peptides and
proteins on an LC timescale.
ECD holds much promise to be a
supplementary dissociation technique to collision-induced
dissociation (CID). In addition, ECD also permits you to
distinguish between leucine and isoleucine residues and even
between D- and L-amino acids. Therefore, ECD in combination
with CID can be used for unambiguous protein identification,
de novo sequencing and complete protein
characterization...more
on Preserving PTMs during Peptide
Fragmentation
Previous: Top-Down
Proteomics with the Finnigan LTQ
FT |
|
| News: Video
Clips, Downloads, Seminars and more... |
 |
-
Introduction to the most sensitive and advanced Triple Quad
[Video
Clip].
- Rapid Accurate Protein Identification
[Video
Clip].
- Download
Proteomics Pioneers Vol.3. including interviews with
experts Neil Kelleher, Gil Omenn, Brad Gibson, David Lubman,
Fred McLafferty, Stan Fields, Lawrence DeLucas, Joshua LaBaer,
Ron Beavis, Hanno Langen, Matthias Mann and Richard
Smith.
- Attend
the European Proteomics Seminar Series.
|
| |
| Proteomics
Applications |
 |
- Large-scale
characterization of HeLa cell nuclear phosphoproteins:
2,002 Phosphorylation sites were determined from 967
proteins using the MS/MS/MS (MS3) capability of the
Finnigan LCQ Deca XP ion trap mass spectrometer with the
XCALIBUR 1.4 software. [Search
Pubmed]
- Characterization of Protein Glycosylation
using ESI Chip Static Nanospray Ion Trap MSn Mass Spectrometry
[Download]
More
Proteomics Applications... |
| |
|
|
| Software -
Enter our Contest |
|
 |
Your opinion matters! We strive every day to improve
the usability of our software and provide features that you
really need. Please take a moment to visit
www.thermo.com/ms-software and tell us what you want.
In return, you will be entered in a drawing to win a free
palmOne(TM) Treo(TM) smartphone. |
| Quantitation?
Think Quantum |
|
 |
Find out why the Finnigan TSQ Quantum is the most
robust triple quad in the market today. [Read
Article]
Previous: Sensitivity
and the Quantum
Next: Linear Dynamic
Range |
| Small
Molecule Applications |
 |
- Trace-Level
Quantitation of Chloramphenicol Using the Finnigan TSQ Quantum
Discovery [Download]
-
Ultra-sensitive LC/MS/MS Quantitation of Lipids in Biological
Fluids [Download]
-
Accurate Mass Determination of a Pharmaceutical Compound
Mixture Using the Finnigan TSQ Quantum Ultra AM [Download]
More
Small Molecule Applications... |
| |
|
| Trap Talk:
Dynamic Exclusion |
|
 |
In
conventional LC/MS/MS experiments a sample is initially
analyzed by mass spectrometry to identify the molecular ions
of the peaks of interest. The sample is then analyzed further
by performing product ion MS/MS scans on the selected peaks.
This is a time-consuming process because the sample needs to
be run at least twice and the MS/MS data is only recorded for
a limited number of components.
Intelligent Data Dependent
experiments were pioneered on Finnigan mass spectrometers to
overcome these limitations. In these experiments the mass
spectrometer performs the MS and MSn scans without any user
intervention. The ion trap mass spectrometer is particularly
well suited to this sort of experiment, not only due to its
inherent sensitivity in full scan mode but also
because...[Read
the full article]
Previous: Wideband
Activation
Next: Neutral Fragment
Filter |
|
|
|
| Through the Customer's
Eyes |
"[Finnigan]
LTQ is easy to use, I don't have to spend
time calibrating and tuning every day, while others are
calibrating I am collecting data"
-- Lance
Wells, Ph.D.
Assistant Professor of Biochemistry &
Molecular Biology
Complex Carbohydrate Research
Center
University of Georgia |
| |
|
|
|
 |
|
|
|
