| The accurate identification of glycopeptides is challenging because of their complex structures, labile nature, and microheterogeneity. A variety of mass spectrometry based techniques for determining the structure of glycopeptides have been used, including Time of Flight (TOF), triple quadrupole, and ion trap, coupled with a variety of ionization techniques including fast atom bombardment (FAB), matrix-assisted laser desorption ionization (MALDI), and electrospray ionization (ESI). This application report describes the use of a static nanospray ionization technique in combination with a novel linear ion trap (LTQ) for identification and characterization of glycosylation in complex mixtures.
To view the complete application note, please download the PDF file on the left of this page.
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